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Pediatric dose of iv ciprofloxacin (4 × 10(5) mg/kg, intramuscularly, as 2 separate doses). Each test dose was administered on separate days with 3–7 of recovery between treatments. This drug was administered to control for the potential effects of coadministration fluoxetine and other pharmaceuticals known to produce psychotogenic effects, as in an open study. All subjects completed the trial within specified time frame and were then randomly assigned to receive the test dose of aripiprazole, placebo or the higher dose of ciprofloxacin. In all, 27 subjects (13 male; mean age 26 years; 14 women; mean age 24 years) were randomized and received study treatments ( Table 1 ). One female and 13 male subjects were excluded from the study after failing a drug screen and adverse event assessment by a board-certified pediatric neurologist. Eight women and seven men were lost to follow-up. A total of 8 patients (6 males; 7 females) who did not receive aripiprazole were randomized to ciprofloxacin or placebo. The drug dosage for trial was as follows: aripiprazole = 30.25 mg/day. The trial was double-blind, randomized and placebo-controlled, with parallel-group designs. The primary outcome was change from baseline in the total score for BPRS-19. Secondary outcome variables included subjective measures, adverse events, clinical laboratory parameters and other measures determined during the study. There were no treatment effects for any individual parameter. The overall effect measure for this outcome variable was a significant reduction in the BPRS-19 total score (F (1,19) = 4.99, P.013). The BPRS-19 total score for aripiprazole-ciprofloxacin group was significantly lower than for the placebo-drug group on day 7 (F (1,19) = 3.89, P.017) and by day 14 (F (1,19) = 3.84, P.032) ( Table 2 ). The BPRS-20 total score was significantly lower than for both the aripiprazole-placebo groups on 1 day and all days. The changes between treatments are shown in a. The results for changes from baseline (day 1) to day 7 and 14 between groups treatment × time are presented using the chi-square test. Significant interactions were detected between treatment and group on all three variables. At day 1, the aripiprazole-placebo and aripiprazole-ciprofloxacin groups showed similar numbers of patients who reported changes from baseline in the total score, BPRS-19, BPRS-20 and both measures of psychotic symptoms. A significant treatment × group interaction was observed on day 7 and 14, with an increase in the BPRS-19 total score only for the aripiprazole-ciprofloxacin group compared with aripiprazole-placebo group. After treatment day 14, there were significant increases in the BPRS-19 total score for aripiprazole-placebo and the aripiprazole-ciprofloxacin groups, but a significant reduction for the aripiprazole group compared with aripiprazole-placebo group. A significant treatment × group interaction was observed for the BPRS-20 total score at day 1. 1 patients who received aripiprazole showed a significantly decreased BPRS-19 total score relative to patients who received aripiprazole alone (P =.008), whereas patients who received placebo did not show an improvement relative to those receiving placebo. At day 7 this difference was no longer significant (P =.16) and patients receiving ciprofloxacin showed a more pronounced decrease than those receiving aripiprazole ( P =.005). At Nz online pharmacy com day 14, there were no significant changes in either of these variables compared with the pretreatment score for either treatment group. The average change in BPRS-19 total score at day 1 during the aripiprazole-ciprofloxacin versus placebo groups and during the aripiprazole-placebo versus groups across day 1 for the aripiprazole-ciprofloxacin, aripiprazole-placebo and groups were −0.3, −0.6 −0.4 (P =.04, P.004, respectively). The effect of aripiprazole-ciprofloxacin (P =.00) and the effect of aripiprazole-placebo.

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